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KMID : 0352419930120040447
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Keimyung Medical Journal
1993 Volume.12 No. 4 p.447 ~ p.454
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Rhodanese Activity in Regenerating Liver after Partial Hepatectomy in Rats
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Abstract
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A study was made on changes of rhodanese activity in regenerating rat liver. Cytosolic, mitochondrial and microsomal rhodanese activities were determined in regenerating liver following 70%(median and left lateral lobes) partial hepatectomy in
rats
over
a period of ten days. The activity of the rhodanese in serum was measured together with the above determination of hepatic enzymes. The values of Km and Vmax in these hepatic enzymes were measured.
The ectivity of cytosolic rhodanese in regenerating rat liver deceased significantly between the first and the sixth day following partial hepatectomy. The activity of mitochondrial rhodanese in regenerating rat liver decreased slightly between
the
first and the third day following partial hepatectomy.
However, the activity of microsomal rhodanese in regenerating rat liver increased slightly between the twelfth hour and the first day following partial hepatectomy.
The value of Vmax of the cytosolic rhodanese in regenerating rat liver showed a significant decrease at the first day following partial hepatectomy, while the Vmax value of the microsomal rhodanese in their livers showed a significant increase.
On
the
other hand, the values of Km of the above hepatic enzymes did not change.
The rhodanese activity in serum decreased significantly between the frist and the sixth day following partial hepatectomy.
Summarizing the view of the above results, cytosolic rhodanese in regenerating rat liver seems to be an enzyme decreasing in its biosynthesis in the regenerating stage, but microsomal rhodanese in the regenerating liver seems to be an enzyme
increasing
in its biosynthesis.
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